Article

Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival

2023-03-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> The microbiome has long been suspected of a role in colorectal cancer (CRC) tumorigenesis. The mutational signature SBS88 mechanistically links CRC development with the strain of Escherichia coli harboring the pks island that produces the genotoxin colibactin, but the genomic, pathological and survival characteristics associated with SBS88-positive tumors are unkn...

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Literature Corpus work: f25ee2df-e04a-56d3-873e-5656ea8892d7
DOI: 10.1101/2023.03.10.23287127

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