Article

Type-I Interferon drives T-cell responses to Amyloid-beta in the central nervous system

2024-10-25

Abstract excerpt

<title>Abstract</title> <p>Amyloid beta (Aβ) plaque deposition in the central nervous system (CNS) is a hallmark of Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA), triggering an innate immune response. However, the role of the adaptive immune system is less clear. We investigated immune microenvironment dynamics in APP23 transgenic (APP23-tg) mice modelling CNS amyloid pathology, using single-cell...

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Literature Corpus work: 354bcdfe-1ffa-5eff-b646-8553108c56c8
DOI: 10.21203/rs.3.rs-5140494/v1

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