Article

Amyloid-beta and tau pathologies are both necessary to induce novel stage-specific microglia subtypes during Alzheimer’s disease progression

2021-10-16

Abstract excerpt

It is unknown whether specific microglia are selectively induced by amyloid-β (Aβ), tau pathologies, or both in combination. To address this, we use single-cell RNA-sequencing to profile mice bearing both Aβ and tau pathologies during Alzheimer’s disease (AD) progression. We identify novel microglia subtypes induced in a disease stage-specific manner. We show that during early-stage disease, interferon signaling i...

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Literature Corpus work: b8dfa58f-7c5a-5bc6-a769-f806addb9e23
DOI: 10.1101/2021.10.16.464454

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