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Article

Identification of plasma inflammatory biomarkers for Alzheimer's disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype.

Frontiers in immunology - 1 Jan 2026

Huang Ronghua, Lin Bing-Biao, Lu Zhijie, Hao Yixuan, Li Chenrui, Lin Zixian, Zhang Yingjie, Wei Naili, Chen Jian

Abstract excerpt

Background: The identification of plasma biomarkers for the diagnosis of Alzheimer's disease (AD) has been a longstanding research priority; however, few plasma biomarkers have yet been implemented in routine clinical practice. Methods: This study enrolled 141 participants, including 71 patients with AD, 44 individuals with mild cognitive impairment, and 28 cognitively healthy controls (HC). A total of 16 plasma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41782881
DOI: 10.3389/fimmu.2026.1770509
PMCID: PMC12953125

Genes

ACSL1
APOE
CCL11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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