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Article

Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.

Cells - 24 Dec 2022

Rudan Njavro Jasenka, Vukicevic Marija, Fiorini Emma, Dinkel Lina, Müller Stephan A, Berghofer Anna, Bordier Chiara, Kozlov Stanislav, Halle Annett, Buschmann Katrin, Capell Anja, Giudici Camilla, Willem Michael, Feederle Regina, Lichtenthaler Stefan F, Babolin Chiara, Montanari Paolo, Pfeifer Andrea, Kosco-Vilbois Marie, Tahirovic Sabina

Abstract excerpt

Amyloid-β (Aβ) deposition is an initiating factor in Alzheimer's disease (AD). Microglia are the brain immune cells that surround and phagocytose Aβ plaques, but their phagocytic capacity declines in AD. This is in agreement with studies that associate AD risk loci with genes regulating the phagocytic function of immune cells. Immunotherapies are currently pursued as strategies against AD and there are increased...

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Identifiers

PMID: 36611872
DOI: 10.3390/cells12010079
PMCID: PMC9818422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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