Article
Differential Control of HIV-1 Replication by IFN-α14 Compared to IFN-α2 Relates to Differences in the Modulation of Host Antiretroviral Restriction Factors
2025-11-03
Abstract excerpt
<h4>ABSTRACT</h4> Type I IFN, including IFN-α, induces the expression of antiviral restriction factors that can interfere with multiple steps of the HIV-1 replication cycle. Humans have 13 IFN-α genes which encode 12 different IFN-α subtypes. Our previous work in HIV-1 infected humanized mice showed that IFN-α14 treatment more potently controlled HIV-1 than treatment with the clinically approved IFN-α2 subtype. H...
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Identifiers and source
- Literature Corpus work
- 3537e01e-cc1a-57f5-9e9d-aad9e21c38b1
- DOI
- 10.1101/2025.11.01.685890