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Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection<i>In Vivo</i>

21 Apr 2016

Abstract excerpt

UNLABELLED: Although all 12 subtypes of human interferon alpha (IFN-α) bind the same receptor, recent results have demonstrated that they elicit unique host responses and display distinct efficacies in the control of different viral infections. The IFN-α2 subtype is currently in HIV-1 clinical trials, but it has not consistently reduced viral loads in HIV-1 patients and is not the most effective subtype against...

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PMID: 27099312
DOI: 10.1128/jvi.00451-16

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