Article

Interferon-α subtype treatment induces the repression of SRSF1 in HIV-1 target cells and affects HIV-1 post integration steps

2021-06-11

Abstract excerpt

Efficient replication of HIV-1 depends on balanced levels of host cell components, including cellular splicing factors. Type I interferons (IFN-I), playing a crucial role in the innate immune defense against viral infections, are well known to induce the transcription of IFN-stimulated genes (ISGs) including potent host restriction factors. Not so well known is, that IFN-repressed genes (IRepGs) also affect viral...

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Literature Corpus work: 5e7791a3-05bd-5bad-b771-40293370ad46
DOI: 10.1101/2021.06.11.448031

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Interferon-α subtype treatment induces the repression of SRSF1 in HIV-1 target cells and affects HIV-1 post integration stepsDOI 10.1101/2021.06.11.448031Read

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