ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction

Abstract excerpt

<h4>SUMMARY</h4> Type I interferon (IFN-I) responses are tightly regulated to balance antiviral defense with cellular homeostasis. In humans, interferon-stimulated gene 15 (ISG15) functions as a critical negative regulator of IFN-I signaling by stabilizing the IFN negative regulator USP18, yet the functional consequences of ISG15 deficiency remain elusive. Here, we show that the loss of ISG15 exaggerates the JAK-...

Topics

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• Cytokine Signaling Pathways and Interactions
• Influenza Virus Research Studies
• interferon and immune responses
• Mosquito-borne diseases and control
• RNA regulation and disease
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

549b6f23-c758-5325-87cd-57368060ee72

DOI

10.64898/2026.03.13.711570