Article

Targeted mutations in IFNα2 improve its antiviral activity against various viruses

2023-09-11

Abstract excerpt

During viral infections, type I interferons (IFN) are induced and play a key role in counteracting initial viral spread. Twelve different human IFNα subtypes exist that bind the same receptor; however, they elicit unique host responses and display distinct potencies of antiviral activities. Our previous studies on HIV and HBV demonstrated that the clinically used IFNα2 is not the most effective one among the IFNα...

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Literature Corpus work: 532cecef-13bc-58b0-86c7-4cc09948f03e
DOI: 10.1101/2023.09.06.556557

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