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Interferons and HIV Infection: The Good, the Bad, and the Ugly

6 Jul 2016

Abstract excerpt

Whether type I interferons (IFNs) hinder or facilitate HIV disease progression is controversial. Type I IFNs induce the production of restriction factors that protect against mucosal HIV/SIV acquisition and limit virus replication once systemic infection is established. However, type I IFNs also increase systemic immune activation, a predictor of poor CD4+ T-cell recovery and progression to AIDS, and facilitate...

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PMID: 27500281
DOI: 10.20411/pai.v1i1.125

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