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IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection

13 Jun 2017

Abstract excerpt

Genetic polymorphisms in IFNL4 have been shown to predict responses to IFN-α-based therapy in hepatitis C virus (HCV)-infected patients. The IFNL4-ΔG genotype, which encodes functional IFN-λ4 protein, is associated with a poor treatment response. In the present study, we investigated the induction and biological effects of IFN-λ4 in HCV-infected hepatocytes and their association with responsiveness to IFN-α. We...

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PMID: 28630501
DOI: 10.1038/s41598-017-04186-7

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