Article

Broad-spectrum RNA antiviral inspired by ISG15 <sup>-/-</sup> deficiency

2024-06-28

Abstract excerpt

<h4>Summary</h4> Type I interferons (IFN-I) are cytokines with potent antiviral and inflammatory capacities. IFN-I signaling drives the expression of hundreds of IFN-I stimulated genes (ISGs), whose aggregate function results in the control of viral infection. A few of these ISGs are tasked with negatively regulating the IFN-I response to prevent overt inflammation. ISG15 is a negative regulator whose absence lea...

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Identifiers and source

Literature Corpus work: e3981315-89b5-507c-8895-fd82275eb2ae
DOI: 10.1101/2024.06.24.600468

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