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A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

6 Dec 2018

Abstract excerpt

Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of Interferon Stimulated Genes (ISGs) into a modified lentiviral vector that allows for packaging of sgRNA-encoding genomes in trans into budding HIV-1 particles. We observed that knockout of Zinc Antiviral Protein (ZAP) improved the...

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PMID: 30520725
DOI: 10.7554/elife.39823

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