Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISG15 deficiency restricts HIV-1 infection

25 Mar 2022

Abstract excerpt

Type I interferons (IFN-Is) are a group of potent inflammatory and antiviral cytokines. They induce IFN stimulated genes (ISGs), which act as proinflammatory mediators, antiviral effectors, and negative regulators of the IFN-I signaling cascade itself. One such regulator is interferon stimulated gene 15 (ISG15). Humans with complete ISG15 deficiency express persistently elevated levels of ISGs, and consequently,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to interferon and immune responses
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35333911
DOI: 10.1371/journal.ppat.1010405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISG15 deficiency restricts HIV-1 infectionPMID 35333911Read ↗

Broad-spectrum RNA antiviral inspired by ISG15 <sup>-/-</sup> deficiencySemantic proximity Read ↗

A novel <i>ISG15</i> transcript restricts influenza A virus infectionSemantic proximity Read ↗

ISG15 deficiency and increased viral resistance in humans but not miceSemantic proximity Read ↗

ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restrictionSemantic proximity Read ↗

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

A Virus-Packageable CRISPR Screen Identifies Host Factors Mediating Interferon Inhibition of HIVSemantic proximity Read ↗

Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cellsSemantic proximity Read ↗

The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response.Semantic proximity Read ↗

ISG15 induces IL-10 production in human monocytes and is a biomarker of disease severity during active tuberculosisSemantic proximity Read ↗

ISG15 expression correlates with HIV-1 viral load and with factors regulating T cell response.Semantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.