Article

Alzheimer’s disease risk variant rs11218343 determines functional expression of <i>SORL1</i> in microglia

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Rs11218343 is a non-coding variant of genome-wide significance for sporadic Alzheimer’s disease (AD) with one of the most protective effects known. It localizes to SORL1 , encoding the AD risk factor SORLA. Still, the functional significance of rs11218343 for AD related processes remains unclear. <h4>Methods</h4> We used iPSC lines from donors, or genome-engineered to c...

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Literature Corpus work: 35309690-342f-512c-8bde-532c3c3fadf7
DOI: 10.64898/2025.12.15.694337

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