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Article

Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2025

Zhou Xiaopu, Cao Han, Jiang Yuanbing, Chen Yuewen, Zhong Huan, Fu Wing Yu, Lo Ronnie Ming Nok, Wong Bonnie Wing Yan, Cheng Elaine Yee Ling, Mok Kin Ying, Kwok Timothy C Y, Mok Vincent C T, Ip Fanny C F, Miyashita Akinori, Hara Norikazu, Ikeuchi Takeshi, Hardy John, Chen Yu, Fu Amy K Y, Ip Nancy Y

Abstract excerpt

INTRODUCTION: The SORL1 locus exhibits protective effects against Alzheimer's disease (AD) across ancestries, yet systematic studies in diverse populations are sparse. METHODS: Logistic regression identified AD-associated SORL1 haplotypes in East Asian (N = 5249) and European (N = 8588) populations. Association analysis between SORL1 haplotypes and AD-associated traits or plasma biomarkers was conducted. The...

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Identifiers

PMID: 39655505
DOI: 10.1002/alz.14214
PMCID: PMC11772736

Genes

SORL1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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