Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.

Archives of neurology - 1 Mar 2012

Caglayan Safak, Bauerfeind Anja, Schmidt Vanessa, Carlo Anne-Sophie, Prabakaran Thaneas, Hübner Norbert, Willnow Thomas E

Abstract excerpt

OBJECTIVE: To identify SORL1 risk genotypes that determine receptor protein expression in the human brain. DESIGN: DNA, RNA, and proteins were extracted from brain autopsies of Alzheimer disease cases and used for SORL1 genotyping, RNA profiling, and SORLA protein quantification, respectively. SETTING: Specimens were provided by the MRC London Brain Bank for Neurodegenerative Diseases and the Netherlands Brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Autopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Chemistry

Share to Enzyme-Linked Immunosorbent Assay

Share to LDL-Receptor Related Proteins

Share to Membrane Transport Proteins

Share to Predictive Value of Tests

Source

Identifiers

PMID: 22410445
DOI: 10.1001/archneurol.2011.788

Genes

SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.PMID 22410445Read ↗

The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.Semantic proximity Read ↗

An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.Semantic proximity Read ↗

Coding mutations in SORL1 and Alzheimer disease.Semantic proximity Read ↗

SORL1 variants across Alzheimer's disease European American cohorts.Semantic proximity Read ↗

Alzheimer’s disease risk variant rs11218343 determines functional expression of <i>SORL1</i> in microgliaSemantic proximity Read ↗

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.Semantic proximity Read ↗

Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease.Semantic proximity Read ↗

A familial missense variant in the Alzheimer's disease gene SORL1 impairs its maturation and endosomal sorting.Semantic proximity Read ↗

Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease.Semantic proximity Read ↗

SORL1 Variants Show Different Association with Early-Onset and Late-Onset Alzheimer's Disease Risk.Semantic proximity Read ↗

SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease.Semantic proximity Read ↗

A familial missense variant in the Alzheimer’s Disease gene <i>SORL1</i> impairs its maturation and endosomal sortingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.