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Article

Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.

The Journal of experimental medicine - 7 Dec 2020

Liu Tongfei, Zhu Bing, Liu Yan, Zhang Xiaoming, Yin Jun, Li Xiaoguang, Jiang LuLin, Hodges Andrew P, Rosenthal Sara Brin, Zhou Lisa, Yancey Joel, McQuade Amanda, Blurton-Jones Mathew, Tanzi Rudolph E, Huang Timothy Y, Xu Huaxi

Abstract excerpt

Variations in many genes linked to sporadic Alzheimer's disease (AD) show abundant expression in microglia, but relationships among these genes remain largely elusive. Here, we establish isogenic human ESC-derived microglia-like cell lines (hMGLs) harboring AD variants in CD33, INPP5D, SORL1, and TREM2 loci and curate a comprehensive atlas comprising ATAC-seq, ChIP-seq, RNA-seq, and proteomics datasets. AD-like...

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Identifiers

PMID: 32941599
DOI: 10.1084/jem.20200474
PMCID: PMC7953740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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