Article

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer’s disease risk gene SORL1

2023-02-25

Abstract excerpt

<h4>Summary</h4> SORL1 is strongly implicated in the pathogenesis of Alzheimer’s disease (AD) through human genetic studies that point to an association of reduced SORL1 levels with higher risk for AD. To interrogate the role(s) of SORL1 in human brain cells, SORL1 null iPSCs were generated, followed by differentiation to neuron, astrocyte, microglia, and endothelial cell fates. Loss of SORL1 led to alterations i...

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Literature Corpus work: 703a5d6c-fafe-524c-88a4-0c63a92c1f03
DOI: 10.1101/2023.02.25.530017

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