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Article

Alzheimer's disease risk single nucleotide polymorphism rs11218343 is linked to functional expression of SORL1 in microglia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2026

Gorniak-Walas Malgorzata, Telugu Narasimha S, Rudolph Ina-Maria, Diecke Sebastian, Willnow Thomas E

Abstract excerpt

INTRODUCTION: The rs11218343 is a non-coding variant of genome-wide significance for sporadic Alzheimer's disease (AD) with one of the most protective effects known to date. It localizes to SORL1, encoding the AD risk factor Sortilin-related receptor with A type repeats (SORLA). Still, the functional significance of rs11218343 for AD-related processes remains unclear. METHODS: We used induced pluripotent stem...

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Identifiers

PMID: 42002722
DOI: 10.1002/alz.71390
PMCID: PMC13092420

Genes

SORL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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