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Alzheimer's Disease Risk Gene SORL1 Promotes Receptiveness of Human Microglia to Pro‐Inflammatory Stimuli

17 Dec 2024

Abstract excerpt

Sorting protein-related receptor containing class A repeats (SORLA) is an intracellular trafficking receptor encoded by the Alzheimer's disease (AD) gene SORL1 (sortilin-related receptor 1). Recent findings argue that altered expression in microglia may underlie the genome-wide risk of AD seen with some SORL1 gene variants, however, the functional significance of the receptor in microglia remains poorly...

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PMID: 39688327
DOI: 10.1002/glia.24659

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