Article

Cryo-EM Structure of Adeno-associated virus-4 at 2.2 Å resolution

2022-01-13

Abstract excerpt

Adeno-associated virus (AAV) is the vector of choice for several approved gene therapy treatments and is the basis for many ongoing clinical trials. Various strains of AAV exist (referred to as serotypes), each with their own transfection characteristics. Here, we present a high-resolution cryo-electron microscopy structure (2.2 Å) for AAV serotype 4 (AAV4). The receptor responsible for transduction of the AAV4 cl...

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Literature Corpus work: 350001ee-9ff3-5c1d-bf3b-e7deab291c88
DOI: 10.1101/2022.01.12.476110

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