Article

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

2022-01-24

Abstract excerpt

Clade F adeno-associated virus (AAV) 9 has been utilized as therapeutic gene delivery vector, and it is capable of crossing blood brain barrier (BBB). Recently, an AAV9 based engineering serotype with enhanced BBB crossing ability, AAVPHP.eB, further expand clade F AAVs’ usages in the central nervous system (CNS) gene delivery. In this study, we determined the cryo-electron microscopy (cryo-EM) structures of the A...

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Identifiers and source

Literature Corpus work: 614b7681-d100-5c40-a903-63b4ebdc4a98
DOI: 10.1101/2022.01.23.477411

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