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Article

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

22 May 2019

Abstract excerpt

Adeno-associated virus (AAV) vectors are preeminent in emerging clinical gene therapies. Generalizing beyond the most tractable genetic diseases will require modulation of cell specificity and immune neutralization. Interactions of AAV with its cellular receptor, AAVR, are key to understanding cell-entry and trafficking with the rigor needed to engineer tissue-specific vectors. Cryo-electron tomography shows...

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PMID: 31115336
DOI: 10.7554/elife.44707

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