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Cryo-electron Microscopy of Adeno-associated Virus

16 May 2022

Abstract excerpt

Adeno-associated virus (AAV) has a single-stranded DNA genome encapsidated in a small icosahedrally symmetric protein shell with 60 subunits. AAV is the leading delivery vector in emerging gene therapy treatments for inherited disorders, so its structure and molecular interactions with human hosts are of intense interest. A wide array of electron microscopic approaches have been used to visualize the virus and...

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PMID: 35575684
DOI: 10.1021/acs.chemrev.1c00936

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