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An alternate receptor for adeno-associated viruses

15 Jul 2025

Abstract excerpt

Systemic gene therapy using adeno-associated virus (AAV) vectors is approved for the treatment of several genetic disorders, but challenges and toxicities associated with high vector doses remain. We report an alternate receptor for AAV (AAVR2, carboxypeptidase D [CPD]), which is distinct from the multi-serotype AAV receptor (AAVR). AAVR2 enables the transduction of clade E AAVs, including AAV8, and determines an...

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PMID: 40664211
DOI: 10.1016/j.cell.2025.06.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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