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Article

Cryo-EM structure of adeno-associated virus 4 at 2.2 Å resolution

10 Jan 2023

Abstract excerpt

Adeno-associated virus (AAV) is the vector of choice for several approved gene-therapy treatments and is the basis for many ongoing clinical trials. Various strains of AAV exist (referred to as serotypes), each with their own transfection characteristics. Here, a high-resolution cryo-electron microscopy structure (2.2 Å) of AAV serotype 4 (AAV4) is presented. The receptor responsible for transduction of the AAV4...

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PMID: 36762860
DOI: 10.1107/s2059798322012190

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