Article
Structure of the AAVhu.37 capsid by cryoelectron microscopy.
Acta crystallographica. Section F, Structural biology communications - 1 Feb 2020
Kaelber Jason T, Yost Samantha A, Webber Keith A, Firlar Emre, Liu Ye, Danos Olivier, Mercer Andrew C
Abstract excerpt
Adeno-associated viruses (AAVs) are used as in vivo gene-delivery vectors in gene-therapy products and have been heavily investigated for numerous indications. Over 100 naturally occurring AAV serotypes and variants have been isolated from primate samples. Many reports have described unique properties of these variants (for instance, differences in potency, target cell or evasion of the immune response), despite...
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