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Capsid Antibodies to Different Adeno-Associated Virus Serotypes Bind Common Regions

13 Jun 2013

Abstract excerpt

Interactions between viruses and the host antibody immune response are critical in the development and control of disease, and antibodies are also known to interfere with the efficacy of viral vector-based gene delivery. The adeno-associated viruses (AAVs) being developed as vectors for corrective human gene delivery have shown promise in clinical trials, but preexisting antibodies are detrimental to successful...

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PMID: 23760240
DOI: 10.1128/jvi.00622-13

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