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Article

Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.

Journal of virology - 1 Dec 2006

Govindasamy Lakshmanan, Padron Eric, McKenna Robert, Muzyczka Nicholas, Kaludov Nikola, Chiorini John A, Agbandje-McKenna Mavis

Abstract excerpt

The adeno-associated viruses (AAVs) can package and deliver foreign DNA into cells for corrective gene delivery applications. The AAV serotypes have distinct cell binding, transduction, and antigenic characteristics that have been shown to be dictated by the capsid viral protein (VP) sequence. To understand the contribution of capsid structure to these properties, we have determined the crystal structure of AAV...

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PMID: 16971437
DOI: 10.1128/JVI.01536-06
PMCID: PMC1642620

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