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Mapping a Neutralizing Epitope onto the Capsid of Adeno-Associated Virus Serotype 8

17 May 2012

Abstract excerpt

Adeno-associated viruses (AAVs) are small single-stranded DNA viruses that can package and deliver nongenomic DNA for therapeutic gene delivery. AAV8, a liver-tropic vector, has shown great promise for the treatment of hemophilia A and B. However, as with other AAV vectors, host anti-capsid immune responses are a deterrent to therapeutic success. To characterize the antigenic structure of this vector,...

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PMID: 22593150
DOI: 10.1128/jvi.00218-12

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