Article

STAT5/Runx3 axis mediates cytotoxic activity in CD4+ T cells during early neuroinflammation

2025-08-07

Abstract excerpt

<title>Abstract</title> <p>CD4+ T cells are crucial for the development of autoimmune neuroinflammation in mice and are widely held to orchestrate the inflammatory cascade and immunopathology. Here, we show that auto-aggressive CD4⁺ T cells acquire a cytotoxic phenotype (CD4-CTL) and function during the early phase of relapsing-remitting multiple sclerosis (RRMS) and in experimental autoimmune encephalomyelitis (...

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Literature Corpus work: 34eb961f-3fd4-52b7-80a0-b4c093bf4c06
DOI: 10.21203/rs.3.rs-7206354/v1

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