Article
Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype.
Frontiers in immunology - 1 Jan 2022
Rasouli Javad, Casella Giacomo, Zhang Weifeng, Xiao Dan, Kumar Gaurav, Fortina Paolo, Zhang Guang-Xian, Ciric Bogoljub, Rostami Abdolmohamad
Abstract excerpt
GM-CSF-producing T helper (Th) cells play a crucial role in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). Recent studies have identified a distinct population of GM-CSF-producing Th cells, named ThGM cells, that also express cytokines TNF, IL-2, and IL-3, but lack expression of master transcription factors (TF) and signature cytokines of commonly recognized Th cell lineages. ThGM cells...
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