Article

Clonal CD8 T cells in the leptomeninges are locally controlled and influence microglia in human neurodegeneration

2023-07-14

Abstract excerpt

Recent murine studies have highlighted a crucial role for the meninges in surveilling the central nervous system (CNS) and influencing CNS inflammation. However, how meningeal immunity is altered in human neurodegeneration and its potential effects on neuroinflammation is understudied. In the present study, we performed single-cell analysis of the transcriptomes and T cell receptor repertoire of 72,576 immune cell...

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Literature Corpus work: 915bdd2a-abfb-5b51-89e5-0f32afe22af9
DOI: 10.1101/2023.07.13.548931

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