Article

Clonal CD8 T Cells Accumulate in the Leptomeninges and Communicate with Microglia in Human Neurodegeneration

2024-01-24

Abstract excerpt

<title>Abstract</title> <p>Murine studies have highlighted a crucial role for immune cells in the meninges in surveilling the central nervous system (CNS) and influencing neuroinflammation. However, how meningeal immunity is altered in human neurodegeneration and its effects on CNS inflammation is understudied. We performed the first single-cell analysis of the transcriptomes and T cell receptor (TCR) repertoire...

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Literature Corpus work: 2769f161-c607-5c09-9a55-36fa49f19d33
DOI: 10.21203/rs.3.rs-3755733/v1

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