Article

Role of follicular CD8+ T cells labeled with B cell helper immunotypes in multiple sclerosis and a murine model

2023-09-01

Abstract excerpt

<h4>Background: </h4> Multiple sclerosis (MS) has been considered to be a T cell-dependent autoimmune disease of the central nervous system (CNS), and so does the experimental autoimmune encephalomyelitis (EAE) model. Recent studies have revealed a specific subset of CD8 T cells, known as CD8 follicular T cells (CD8 + CXCR5 + T), are involved in antiviral, anti-tumor immunity, and systemic autoimmunity. While the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16c1ce8d-7edf-531d-9145-392bfd824f9d
DOI: 10.21203/rs.3.rs-3305043/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role of follicular CD8+ T cells labeled with B cell helper immunotypes in multiple sclerosis and a murine modelDOI 10.21203/rs.3.rs-3305043/v1Read

Clonal CD8 T Cells Accumulate in the Leptomeninges and Communicate with Microglia in Human NeurodegenerationSemantic proximity Read

STAT5/Runx3 axis mediates cytotoxic activity in CD4+ T cells during early neuroinflammationSemantic proximity Read

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic <i>Trypanosoma brucei</i> infectionSemantic proximity Read

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosisSemantic proximity Read

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosisSemantic proximity Read

CD8<sup>+</sup>T cells in multiple sclerosisSemantic proximity Read

Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guiltySemantic proximity Read

Imaging guided single-cell multiomics unveils shared autoreactive CD4+ T-cell responses in blood, locoregional lymph node and affected tissues of patients with systemic autoimmunitySemantic proximity Read

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis.Semantic proximity Read

T peripheral helper cells in autoimmune diseases*Semantic proximity Read

Mass Cytometry of CSF Identifies an MS-Associated B-cell Population.Semantic proximity Read

Clonal CD8 T cells in the leptomeninges are locally controlled and influence microglia in human neurodegenerationSemantic proximity Read