Tissue-resident CD8 + T cells drive compartmentalized and chronic autoimmune damage against CNS neurons

Abstract excerpt

The mechanisms underlying the chronicity of autoimmune diseases of the central nervous system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident memory T cells (T RM ) contribute to lesion pathogenesis during chronic CNS autoimmunity. Here, we observed that a high frequency of brain-infiltrating CD8 + T cells exhibit a T RM -like phenotype in human autoimmune encephalitis. Using mouse...