Article

RUNX2 is a cell-intrinsic brake on Th17 pathogenicity driven by neutrophil extracellular traps

2025-06-30

Abstract excerpt

Th17 cells are crucial mediators of protective immunity against extracellular pathogens but also promote inflammatory responses in pathological settings such as MS. Distinct transcriptional programs can generate Th17 populations termed pathogenic or non-pathogenic. Understanding the transcriptional regulation of these T cell states is emerging and presents opportunities to modulate pathogenic T cell responses. In...

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Literature Corpus work: 576a7c13-2f5c-55e5-91b9-d7c19d84d435
DOI: 10.1101/2025.06.26.661866

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