Article

Cytotoxic Activity of CD4 T Cells During the Early Stage of Autoimmune Neuroinflammation

2020-03-11

Abstract excerpt

Pathogenic CD4+ T cells are capable of initiating neuroinflammation in experimental autoimmune encephalomyelitis (EAE). However, the precise effector mechanism of these autoaggressive CD4+ T cells is not entirely elucidated. Here, we demonstrated that pathogenic CD4+ T cells, upon autoantigen stimulation, developed a cytotoxic phenotype at the onset of EAE. The cytotoxic activity of pathogenic CD4+ T cells was suf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1412114-a42e-58b5-ae48-edb1f966dcf1
DOI: 10.1101/2020.03.10.985614

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cytotoxic Activity of CD4 T Cells During the Early Stage of Autoimmune NeuroinflammationDOI 10.1101/2020.03.10.985614Read

CD8+ T-Cells as Immune Regulators of Multiple SclerosisSemantic proximity Read

STAT5/Runx3 axis mediates cytotoxic activity in CD4+ T cells during early neuroinflammationSemantic proximity Read

Pathogenic CD8 T Cells in Multiple Sclerosis and Its Experimental ModelsSemantic proximity Read

Tissue-resident CD8 + T cells drive compartmentalized and chronic autoimmune damage against CNS neuronsSemantic proximity Read

Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal ModelsSemantic proximity Read

The Era of Cytotoxic CD4 T CellsSemantic proximity Read

Cytotoxic human CD4(+) T cells.Semantic proximity Read

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosisSemantic proximity Read

Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guiltySemantic proximity Read

B Cells Drive MHC Class I–Restricted CD4 T Cells to Induce Spontaneous Central Nervous System AutoimmunitySemantic proximity Read

CD8<sup>+</sup>T cells in multiple sclerosisSemantic proximity Read

Pathogenic CD8(+) T cells in multiple sclerosis.Semantic proximity Read