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Integrating spatial transcriptomics and snRNA-seq data enhances differential gene expression analysis results of AD-related phenotypes

2024-11-18

Abstract excerpt

<h4>Background</h4> Spatial transcriptomics ( ST ) data provide spatially-informed gene expression for studying complex diseases such as Alzheimer’s disease ( AD ). Existing studies using ST data to identify genes with spatially-informed differential gene expression ( DGE ) of complex diseases have limited power due to small sample sizes. Conversely, single-nucleus RNA sequencing ( snRNA-seq ) data offer larger sa...

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Literature Corpus work: 8319148a-a5df-5feb-bc92-6e1abce835a7
DOI: 10.1101/2024.11.18.24317499

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