Article

Integrated single-cell analysis reveals interferon-driven immune signatures in a DENV1 human infection model

2026-01-05

Abstract excerpt

Dengue virus infection triggers complex innate and adaptive immune responses, yet the molecular mechanisms that shape early antiviral immunity remain incompletely defined. We performed longitudinal single-cell multi-omics profiling of peripheral blood mononuclear cells from four flavivirus-naïve adults experimentally infected with DENV-1, integrating 5′ scRNA-seq with paired surface proteomics. Across 95,841 high-...

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Literature Corpus work: 34c5a66d-3d6d-5748-b885-4173405ab8d9
DOI: 10.64898/2026.01.04.697597

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