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Integrative bulk and single‐cell transcriptome profiling analysis reveals IFI27 as a novel interferon‐stimulated gene in dengue

27 Mar 2023

Abstract excerpt

The dengue virus (DENV) is a public health threat to humans. Increased vascular permeability, coagulopathy, and hemorrhagic diathesis are the pathophysiological hallmarks of severe dengue. However, although the interferon (IFN)-mediated innate immune response forms the backbone of cell-autonomous defense against pathogens, the exact IFN-stimulated genes (ISGs) involved in DENV infection remain to be determined....

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PMID: 36971141
DOI: 10.1002/jmv.28706

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