Article

Antibody-dependent DENV infection induces distinct transcriptomic responses in infected and bystander human macrophages

2024-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Dengue virus (DENV) is a mosquito-borne flavivirus which coexists as four genetically and immunologically distinct serotypes (DENV1-4). In secondary heterologous DENV infection, pre-existing immunity is believed to contribute to severe disease through antibody dependent enhancement (ADE). Although the elevated pathology observed in ADE conditions has been described, the cell intrinsic mechanisms...

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Literature Corpus work: f613d643-60b4-5399-be0d-8149570a2ba8
DOI: 10.1101/2024.07.11.603036

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