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Conventional and antibody-enhanced DENV infection of human macrophages induces differential immunotranscriptomic profiles

4 Feb 2025

Abstract excerpt

Dengue virus (DENV) is a mosquito-borne flavivirus which coexists as four genetically and immunologically distinct serotypes (DENV-1 to -4). In secondary heterologous DENV infection, pre-existing immunity is believed to contribute to severe disease through antibody-dependent enhancement (ADE). Although the elevated pathology observed in ADE conditions has been described, the cell-intrinsic mechanisms governing...

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PMID: 39902963
DOI: 10.1128/jvi.01962-24

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