Article

Global and cell type-specific immunological hallmarks of severe dengue progression

2022-12-14

Abstract excerpt

Severe dengue (SD) is a major cause of morbidity and mortality impacting approximately 5 million of the 400 million people infected with dengue virus (DENV) annually. To define DENV target cells and immunological hallmarks of SD progression in children’s blood, we integrated virus-inclusive single cell RNA-Seq 2 (viscRNA-Seq 2) with functional assays. Beyond myeloid cells, in natural infection, B cells harbor repl...

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Literature Corpus work: 1a6ed429-60fe-546c-9bce-4d55bb0bfa11
DOI: 10.1101/2022.12.11.519930

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