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Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

19 Jun 2024

Abstract excerpt

. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, transient and sustained infections in seronegative individuals challenged with pre-Alpha SARS-CoV-2. Our analyses revealed rapid changes in cell-type proportions and dozens of highly dynamic cellular response states in epithelial and immune cells associated...

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PMID: 38898278
DOI: 10.1038/s41586-024-07575-x

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