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Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue

7 Dec 2018

Abstract excerpt

Dengue virus (DENV) infection can result in severe complications. However, the understanding of the molecular correlates of severity is limited, partly due to difficulties in defining the peripheral blood mononuclear cells (PBMCs) that contain DENV RNA in vivo. Accordingly, there are currently no biomarkers predictive of progression to severe dengue (SD). Bulk transcriptomics data are difficult to interpret...

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PMID: 30530648
DOI: 10.1073/pnas.1813819115

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