Article

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains

2024-07-18

Abstract excerpt

The four-dengue virus (DENV) serotypes cause several hundred million infections annually. Several live-attenuated tetravalent dengue vaccines (LAVs) are at different stages of clinical testing and regulatory approval. A major hurdle faced by the two leading LAVs is uneven replication of vaccine serotypes stimulating a dominant response to one serotype at the expense of the other three, leading to the potential for...

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Literature Corpus work: 34b64a3e-436d-5e8f-b941-e2f6ee7446d4
DOI: 10.1101/2024.07.18.604114

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