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Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains

16 Apr 2025

Abstract excerpt

The four dengue virus (DENV) serotypes cause several hundred million infections annually. Several live-attenuated tetravalent dengue vaccines (LAVs) are at different stages of clinical testing and regulatory approval. A major hurdle faced by the two leading LAVs is uneven replication of vaccine serotypes stimulating a dominant response to one serotype at the expense of the other three, leading to the potential...

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Mosquito-borne diseases and control
Viral Infections and Outbreaks Research
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40237498
DOI: 10.1128/jvi.00229-25

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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